Manual sync on Windows
It seems that Proton Drive only syncs documents when the last change value changes, not when the file actually changed, which creates a problem. Windows has this annoying quirk where, if the file size didn't change, it won't update the meta data for the time the document was last saved, so even if you saved 10 times in 10 minutes, if the changes you made summed up to the same file size, Explorer will continue to show the change time as being 10 minutes prior, and the updated file with not be automatically synced. To bypass that you should add a "Sync now" button next to "Pause sync," to force a hash check, or add a right click context menu to files force a sync.
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Michael
commented
It's worth noting that this is a workaround to what I would argue is probably a bug, because it means your files aren't always updated. That said, I don't know how to fix it on the back-end. The current workaround I have found is if you are actively working on a file, open the Proton Drive app, check when it was last synced, and if there is a mismatch, save the file with a different name, delete the original, then rename the saved-as file.